• Masculine, handsome man in front of a lake

Regenerative Hair Loss Treatments

bruce willis showing that hair loss doesn't hurt attractiveness

I'm a man and I will beat up anybody who tries to tell me I'm not a man just because my hair is thinning.— Actor Bruce Willis (who's handsome either way)

Has there ever been a time like now when a youthful appearance is so important? Losing one's hair can lead to depression and low self-esteem, according to the American Hair Loss Association, and they note “it affects interpersonal relationships as well as the professional lives of those suffering. It is not uncommon for men to change their career paths because of their hair loss.” 

Hair loss can be caused by genetics, medications, stress, aging, medical conditions, and hormones.  Hereditary hair loss with aging, also known as androgenetic alocpecia, is the most common cause of thinning hair or baldness in both men and women. Nearly 85% of men experience hair thinning by the age of 50 and about 40% of women by the age of 40. 

Men tend to lose hair from the temples, in front of their forehead, and the top of their heads.  Women usually experience thinning mostly across the top of their scalp, usually noticed first as a widening part. Ironically, women also tend to notice brow hairs becoming sparser as lower face hairs ("boar bristles") sprout more

diagrams illustrating the changes in hair follicles and blood supply with male pattern baldnessEach hair follicle seems to function as an individual, with its own growth cycle timing. For unknown reasons, some of the scalp follicles become more sensitive to the effects of hormones with aging, especially dihydrotestosterone, or DHT, a byproduct of testosterone. DHT causes the growth phase of the hair to shorten and the follicles to shrink until they no longer produce hair. 

Until recently, the only effective treatments for hair thinning were drugs such as minoxidil and finasteride or hair transplants, but new regenerative treatments are showing great promise.

Exosomes, nanofat and platelet-rich plasma (PRP) use the healing substances found in your own body to regenerate hair growth

Exosomes are tiny packets of substances containing RNA and proteins that bud off of cells and carry their messaging contents to other cells. These little vesicles contain more growth and signaling factors than platelets.

illustrating release of exosomes

Illustrations of the release of packets of exosomes

In the past few years, research has shown the amazing therapeutic potential for the use of stem cell-derived exosomes to treat degenerative, inflammatory, autoimmune, metabolic, and malignant conditions, as well as injuries.

Now, exosomes are the newest treatment option for hair loss in regenerative medicine. 

Unlike PRP or nanofat that require drawing blood or having a mini-liposuction, purified placental exosome solutions are available from tissue banks so treatments require only simple injections, and usually results from a single treatment are seen in between three and six months.

Because exosomes are obtained from commercial sources, the treatments have a higher cost than treatments utilizing your own cells like PRP & nanofat.

There's little research so far to determine the optimal dose of exosomes for different conditions and a wide variation in how exosome numbers in commercial preparations are calculated, so Skinspirations uses XO-GLO purified mesenchymal stem cell-derived exosomes produced by Kimera (kimeralabs.com). Kimera XO-GLO exosomes are produced from neonatal, rigorously screened placental tissue donated after healthy C-sections. This product undergoes thorough screening, sterility and endotoxin testing before being released from quarantine.

injection abdomen exosomesNanofat is a regenerative treatment with even more promising effects than PRP on hair loss, probably because nanofat also contains stem cells in addition to the growth factors found in PRP alone. The name "nanofat" is a misnomer since it's not fat but the healing factors and stem cells that have been filtered out from a small amount of a patient's own fat that is used in regenerative treatments. Nanofat is often mixed with PRP to treat hair loss and results are usually seen with just one treatment.

Platelet Rich Plasma (PRP) has shown improvement in hair loss patients in some studies, especially when a series of treatments are done. Platelets are cells in our blood that are rich in many types of signaling and growth factors and PRP is the liquid portion of the blood in which the platelets have been concentrated and the other blood cells removed. The effects of PRP on hair loss are thought to be due to the effects of the platelet growth factors on the hair follicles. PRP is obtained by drawing a small blood sample & then spinning the tubes to separate out the red and white blood cells while isolating the concentrated platelets. The solution is then injected into the anesthetized portion of the scalp or brows where hair thickening is desired.

After an initial series of 3 bi-monthly PRP treatments, roughly 30% of patients will see an increase in hair growth, 30% won't see an increase but they won't continue to experience hair loss in the months after treatment, and 30% won't see any change. 

PRP, nanofat and/or exosome hair thickening treatments are all applied either with injections or during a microneedling treatment, after anesthetic cream, to get down to the level of the hair follicles.

Depending on the cause of your hair thinning, medications like progesterone, vitamin D and/or finasteride can be added to the injections to improve results. Alopecia areata is an autoimmune-related disease that causes patchy bald areas, & some studies have also shown improvement in the condition with these treatments. Regenerative hair therapies are not effective if the area being treated has no remaining hair follicles, so it's best to start early.

Maintenance treatments are recommended for all of these treatments as needed to maintain results.

The fees for our regenerative hair loss treatment are:

Exosome hair treatment: Regular: $2400,  Small area: $1900

Nanofat hair treatment: $950

PRP hair treatment package of 3: $1,260

Call us at 727-571-1923 for a complimentary consultation to learn if this procedure is right for you!